Antimicrobial Therapy Strategy Using Pragmatic Design in IPF
This study is a randomized, unblinded clinical trial to evaluate the relationship between long term antimicrobial therapy and a decrease in hospital visits for respiratory problems between 12 to 36 months to subjects with idiopathic pulmonary fibrosis (IPF). The purpose of this study is to compare the effect of standard care versus standard care plus antibiotic therapy (co-trimoxazole or doxycycline) on reducing harmful infections that could lead to hospital visits or death in patients diagnosed with IPF. Both co-trimoxazole and doxycycline are FDA approved antibiotics but are not approved for protecting IPF patients from possible bacterial infection. The study involves approximately three to five in-person visits and five telephone calls to determine if subjects are having any problems related to the study or have any breathing problems or hospital visits.