Biorepository for ILDs
The purpose of this research tissue bank is to collect process and store samples until researchers need them to do research. Tissue samples in this bank will be used to further our understanding of interstitial lung diseases (ILDs). There are many different ILDs, including idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILDs (CTD-ILDs), sarcoidosis, hypersensitivity pneumonitis, asbestosis, and many others. In general, these diseases are characterized by a combination of inflammation and fibrosis (or scarring) in the lungs. Unfortunately, once fibrosis develops, it can progressively worsen over time, and it does not respond well to currently available medical therapies. The reasons why some patients develop ILDs are often not clear. Furthermore, the reasons why some patients with ILDs develop progressive lung fibrosis, while others do not, are also poorly understood. Therefore, this research is important to better understand how ILDs develop and progress, so that we may be able to prevent these diseases and treat them more effectively in the future.
This biorepository involves a blood draw of approximately 1 tablespoon from a vein in your arm. For certain patients, you may also be asked to perform an exhaled breath condensate. We will also periodically check your medical record to look at disease progression and treatment.
The primary objective is to collect, store, and analyze plasma from subjects with ILDs in order to identify biomarkers which can predict disease development, severity, and/or progression, and to identify novel pathways involved in the pathogenesis of these diseases. Other objectives are to collect, store, and analyze DNA from subjects with ILDs in order to identify genetic factors which may influence the development, severity, and/or progression of disease.