News

Scientists Evaluate Therapeutic Candidates for Progressive Fibrosis Using a New Experimental Model

Dec 13, 2019

A new experimental model replicates the main steps leading to progressive fibrosis, and can be used to assess the properties of therapeutic candidates.

Study Highlights Gaps in Care for People with Pulmonary Fibrosis in Europe

Nov 25, 2019

Delays in diagnosis and difficulty getting timely access to appropriate specialist care and treatment were highlighted as major gaps in care in a recent survey of people with pulmonary fibrosis and their healthcare providers.

Model of IPF Details Gene Changes at Specific Disease Stages

Nov 19, 2019

Animal models for IPF work to show how pulmonary fibrosis impacts the lungs, but not what regulates changes at the genetic level to drive IPF progression in humans. A new model for investigating human IPF aims at understanding the gene expression changes and molecular regulators that characterize the progression of IPF from histologically normal regions into end-stage disease.

Meta-Analysis Concludes That Viral Infections Raise Risk of Ipf but Not of Acute Exacerbations

Nov 18, 2019

A number of genetic and environmental factors, including viral infections, have been identified as being closely related to the initiation and progression of IPF. A new meta-analysis finds that infection with some viruses could be a potential risk factor for developing IPF but not for acute exacerbation of IPF.

Experimental Study Suggests New Paradigm for Lung Fibrosis Development Involving Blood-Derived Immune Cells

Nov 15, 2019

Long-held dogma that idiopathic pulmonary fibrosis results from recurrent injury to alveolar epithelium that is followed by dysregulated repair. A new experimental study challenges that paradigm, and it suggests a possible treatment target for lung fibrosis.